Hydrochloric Acid → HCID 178466584, compound

HRID 1746321Notes

Reaction equation

[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:44])[N:5]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]#[C:39][Si](C)(C)C)[CH:33]=1)[C:6]([CH:12]([NH:14][C:15]1[N:23]=[CH:22][N:21]=[C:20]3[C:16]=1[N:17]=[CH:18][N:19]3COCC[Si](C)(C)C)[CH3:13])=[N:7]2.Cl.C[OH:47]>>[C:38]([C:34]1[CH:33]=[C:32]([N:5]2[C:4](=[O:44])[C:3]3[C:8](=[CH:9][CH:10]=[CH:11][C:2]=3[CH3:1])[N:7]=[C:6]2[CH:12]([NH:14][C:15]2[N:23]=[CH:22][N:21]=[C:20]3[C:16]=2[N:17]=[CH:18][NH:19]3)[CH3:13])[CH:37]=[CH:36][CH:35]=1)(=[O:47])[CH3:39]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 671035585-Methyl-2-(1-[9-(2-trimethylsilylethoxymethyl)-9H-purin-6-ylamino]ethyl)-3-(3-trimethylsilylethynyiphenyl)-3H-quinazolin-4-one

Product 1

HCID 178466584HCID 178466584, compound

Procedure

Compound 139 was treated with 4N HCl in MeOH at 70° C. for 16 hours in accordance with the procedure described for compound 0.121 (step D). This reaction afforded compound 144, the structure of which is shown below. m/z=440 (M+H)

Sources & evidence

ORD record: ord-dc069daa4d944a06a72f426e5e27d8ed
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09149477B2

Reaction notes

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