Triethylamine → HCID 86655444, compound

HRID 1746485Notes

Reaction equation

HRID 1746485 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.C(N(CC)CC)C.[CH3:25][O:26][C:27]1[CH:37]=[CH:36][CH:35]=[CH:34][C:28]=1[CH:29]=[CH:30][C:31](O)=[O:32].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[CH3:25][O:26][C:27]1[CH:37]=[CH:36][CH:35]=[CH:34][C:28]=1[CH:29]=[CH:30][C:31]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:32]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 268622-Propenoic acid, 3-(methoxyphenyl)-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2734891Methyl tryptophanate hydrochloride

Product 1

HCID 86655444HCID 86655444, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-tryptophanate hydrochloride (4.0 g), triethylamine (4.8 mL), 2-methoxycinnamic acid (3.1 g), WSC.HCl (3.3 g), and methylene chloride (150 mL), to give the captioned compound (5.2 g, 88%) as an oily product.

Sources & evidence

ORD record
ord-852580d73a7d40039a3fb57e4552e5fc
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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