Triethylamine → HCID 86655449, compound

HRID 1746490Notes

Reaction equation

HRID 1746490 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.C(N(CC)CC)C.[F:25][C:26]([F:43])([F:42])[C:27]1[CH:28]=[C:29]([CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=1)[CH:30]=[CH:31][C:32](O)=[O:33].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:25][C:26]([F:42])([F:43])[C:27]1[CH:28]=[C:29]([CH:30]=[CH:31][C:32]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)=[O:33])[CH:35]=[C:36]([C:38]([F:39])([F:40])[F:41])[CH:37]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2734891Methyl tryptophanate hydrochlorideHCID 27732123,5-Bis(trifluoromethyl)cinnamic acid

Product 1

HCID 86655449HCID 86655449, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-tryptophanate hydrochloride (3.0 g), triethylamine (2.0 mL), 3,5-bis(trifluoromethyl)cinnamic acid (4.0 g), WSC.HCl (2.7 g), and methylene chloride (80 mL), to give the captioned compound (2.6 g, 64%) as crystals.

Sources & evidence

ORD record
ord-c706b93e6a4642c2be0649c56d8c34bf
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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