Triethylamine → HCID 86655451, compound

HRID 1746492Notes

Reaction equation

HRID 1746492 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.C(N(CC)CC)C.[O:25]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[CH:27]=[C:26]1[C:34](O)=[O:35].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[O:25]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[CH:27]=[C:26]1[C:34]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:35]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 10331Benzofuran-2-carboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2734891Methyl tryptophanate hydrochloride

Product 1

HCID 86655451HCID 86655451, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-tryptophanate hydrochloride (4.0 g), triethylamine (2.2 mL), benzofuran-2-carboxylic acid (3.1 g), WSC.HCl (3.6 g), and methylene chloride (100 mL), to give the captioned compound (5.6 g, 98%) as an oily product.

Sources & evidence

ORD record
ord-4c9698863058423cbc0eae836f5be87a
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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