Triethylamine → HCID 12237954, compound

HRID 1746493Notes

Reaction equation

HRID 1746493 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.C(N(CC)CC)C.[O:25]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[C:28]([C:36](O)=[O:37])[C:26]1=[O:27].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[O:25]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[C:28]([C:36]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][CH:6]=2)=[O:37])[C:26]1=[O:27]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 10752Coumarin-3-Carboxylic AcidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2734891Methyl tryptophanate hydrochloride

Product 1

HCID 12237954HCID 12237954, compoundYield 43.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-tryptophanate hydrochloride (3.0 g), triethylamine (2.0 mL), coumarin-3-carboxylic acid (2.7 g), WSC.HCl (2.7 g), and methylene chloride (80 mL), to give the captioned compound (2.0 g, 43%) as an oily product.

Sources & evidence

ORD record
ord-b5a4bb3d2a95405d97172f9af0d65327
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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