Triethylamine → HCID 86655461, compound

HRID 1746504Notes

Reaction equation

HRID 1746504 reaction equation
Cl.[CH:2]([N:4]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:6]([CH2:7][C@@H:8]([C:10]([O:12][CH3:13])=[O:11])[NH2:9])=[CH:5]1)=[O:3].C(N(CC)CC)C.[F:27][C:28]1[CH:38]=[CH:37][CH:36]=[CH:35][C:29]=1[CH:30]=[CH:31][C:32](O)=[O:33].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:27][C:28]1[CH:38]=[CH:37][CH:36]=[CH:35][C:29]=1[CH:30]=[CH:31][C:32]([NH:9][C@H:8]([C:10]([O:12][CH3:13])=[O:11])[CH2:7][C:6]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:4]([CH:2]=[O:3])[CH:5]=1)=[O:33]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 67134472HCID 67134472, compound

Product 1

HCID 86655461HCID 86655461, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 29 (4.0 g), triethylamine (2.2 mL), 2-fluorocinnamic acid (2.6 g), WSC.HCl (3.0 g), and methylene chloride (100 mL), to give the captioned compound (4.8 g, 86%) as an oily product.

Sources & evidence

ORD record
ord-752b15bb65404b5e9b4b7b48cb3f0608
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…