Acrylic Acid → HCID 86655463, compound

HRID 1746507Notes

Reaction equation

HRID 1746507 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.[C:17](O)(=[O:20])[CH:18]=[CH2:19].C1CCC(N=C=NC2CCCCC2)CC1.C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:17]([NH:10][C@H:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:16][CH:15]=1)(=[O:20])[CH:18]=[CH2:19]

Participants

6

Reactant 4

HCID 6581Acrylic AcidHCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655463HCID 86655463, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The same procedures as in Example 1 were carried out from the compound obtained in Example 33 (3.3 g), acrylic acid (1.1 mL), DCC (3.4 g), triethylamine (9.5 mL, 68.2 mmol), and chloroform (140 mL), to give the captioned compound (2.1 g, 58%) as crystals.

Sources & evidence

ORD record
ord-1f855bd5f4df4e9ab1b2290a6160ee70
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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