Triethylamine → HCID 86655464, compound

HRID 1746508Notes

Reaction equation

HRID 1746508 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:24]([O:27][C:28]1[CH:38]=[CH:37][CH:36]=[CH:35][C:29]=1[CH:30]=[CH:31][C:32](O)=[O:33])(=[O:26])[CH3:25].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[C:24]([O:27][C:28]1[CH:38]=[CH:37][CH:36]=[CH:35][C:29]=1[CH:30]=[CH:31][C:32]([NH:10][C@H:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:16][CH:15]=1)=[O:33])(=[O:26])[CH3:25]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 414862-Acetoxycinnamic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655464HCID 86655464, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (8.0 g), triethylamine (5.4 mL), 2-acetoxycinnamic acid (8.1 g), WSC.HCl (7.5 g), and methylene chloride (200 mL), to give the captioned compound (8.8 g, 68%) as crystals.

Sources & evidence

ORD record
ord-8d599ffc9b0842059917cb11074f02b4
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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