Triethylamine → HCID 86655465, compound

HRID 1746509Notes

Reaction equation

HRID 1746509 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:24]([O:27][C:28]1[CH:29]=[C:30]([CH:36]=[CH:37][CH:38]=1)[CH:31]=[CH:32][C:33](O)=[O:34])(=[O:26])[CH3:25].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[C:24]([O:27][C:28]1[CH:29]=[C:30]([CH:31]=[CH:32][C:33]([NH:10][C@H:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][C:7]2[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:16][CH:15]=2)=[O:34])[CH:36]=[CH:37][CH:38]=1)(=[O:26])[CH3:25]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 140679HCID 140679, compoundHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655465HCID 86655465, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (2.0 g), triethylamine (1.4 mL), 3-acetoxycinnamic acid (2.0 g), WSC.HCl (1.9 g), and methylene chloride (60 mL), to give the captioned compound (3.1 g, 96%) as an oily product.

Sources & evidence

ORD record
ord-b3720bb3659142c4bf28246e8189c7ec
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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