Triethylamine → HCID 86655469, compound

HRID 1746513Notes

Reaction equation

HRID 1746513 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.C(N(CC)CC)C.[F:24][C:25]1[CH:35]=[CH:34][C:28]([CH:29]=[CH:30][C:31](O)=[O:32])=[CH:27][CH:26]=1.CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:24][C:25]1[CH:26]=[CH:27][C:28]([CH:29]=[CH:30][C:31]([NH:10][C@H:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][C:7]2[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:16][CH:15]=2)=[O:32])=[CH:34][CH:35]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 980703-(4-Fluorophenyl)-2-propenoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655469HCID 86655469, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (2.5 g), triethylamine (3.1 mL), 4-fluorocinnamic acid (1.9 g), WSC.HCl (2.1 g), and methylene chloride (100 mL), to give the captioned compound (2.5 g, 69%) as an amorphous solid product.

Sources & evidence

ORD record
ord-36b4cebf6e2145eeae0152492c22686b
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…