Triethylamine → HCID 86655472, compound

HRID 1746516Notes

Reaction equation

HRID 1746516 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.C(N(CC)CC)C.[F:24][C:25]([F:38])([F:37])[C:26]1[CH:36]=[CH:35][CH:34]=[CH:33][C:27]=1[CH:28]=[CH:29][C:30](O)=[O:31].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH:10][C:30](=[O:31])[CH:29]=[CH:28][C:27]2[CH:33]=[CH:34][CH:35]=[CH:36][C:26]=2[C:25]([F:37])([F:38])[F:24])=[CH:15][CH:16]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 749393-(2-(Trifluoromethyl)phenyl)-2-propenoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655472HCID 86655472, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (2.5 g), triethylamine (1.7 mL), 2-trifluoromethylcinnamic acid (2.6 g), WSC.HCl (2.3 g), and methylene chloride (70 mL), to give the captioned compound (4.1 g, 99%) as an amorphous solid product.

Sources & evidence

ORD record
ord-59ce90a7f77e4f9ab720f1cde19402ad
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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