Triethylamine → HCID 86655479, compound

HRID 1746524Notes

Reaction equation

HRID 1746524 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][C@@H:9]([C:11]([O:13][CH3:14])=[O:12])[NH2:10])=[CH:6][CH:5]=1.C(N(CC)CC)C.[O:24]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[C:27]([C:35](O)=[O:36])[C:25]1=[O:26].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[O:24]1[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[C:27]([C:35]([NH:10][C@H:9]([C:11]([O:13][CH3:14])=[O:12])[CH2:8][C:7]2[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:16][CH:15]=2)=[O:36])[C:25]1=[O:26]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 10752Coumarin-3-Carboxylic AcidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 69612215(S)-Methyl 2-amino-3-(4-methoxyphenyl)propanoate hydrochloride

Product 1

HCID 86655479HCID 86655479, compoundYield 72.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from the compound obtained in Example 33 (2.5 g), triethylamine (1.7 mL), coumarin-3-carboxylic acid (2.3 g), WSC.HCl (2.3 g), and methylene chloride (70 mL), to give the captioned compound (2.8 g, 71%) as crystals.

Sources & evidence

ORD record
ord-cb2feec973264a38bf8f34e434f0e4ff
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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