Triethylamine → HCID 67312694, compound

HRID 1746525Notes

Reaction equation

HRID 1746525 reaction equation
Cl.[NH2:2][C@H:3]([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].C(N(CC)CC)C.[F:19][C:20]1[CH:30]=[CH:29][CH:28]=[CH:27][C:21]=1[CH:22]=[CH:23][C:24](O)=[O:25].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:19][C:20]1[CH:30]=[CH:29][CH:28]=[CH:27][C:21]=1[CH:22]=[CH:23][C:24]([NH:2][C@H:3]([C:8]([O:10][CH3:11])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6])=[O:25]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 2723695Leucine methyl ester hydrochlorideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 67312694HCID 67312694, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-leucinate hydrochloride (3.0 g), triethylamine (2.5 mL), 2-fluorocinnamic acid (3.0 g), WSC.HCl (3.5 g), and methylene chloride (100 mL), to give the captioned compound (4.3 g, 88%) as crystals.

Sources & evidence

ORD record
ord-b1d822d1e6d64a749ebeb3e6f0db21bb
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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