Triethylamine → HCID 67130619, compound

HRID 1746526Notes

Reaction equation

HRID 1746526 reaction equation
Cl.[NH2:2][C@H:3]([C:6]([O:8][CH3:9])=[O:7])[CH2:4][OH:5].C(N(CC)CC)C.[F:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[CH:20]=[CH:21][C:22](O)=[O:23].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[F:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[CH:20]=[CH:21][C:22]([NH:2][C@H:3]([C:6]([O:8][CH3:9])=[O:7])[CH2:4][OH:5])=[O:23]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 2723730L-Serine, methyl ester, hydrochloride (1:1)HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 67130619HCID 67130619, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 2 were carried out from methyl L-serinate hydrochloride (2.5 g), triethylamine (2.4 mL), 2-fluorocinnamic acid (2.8 g), WSC.HCl (3.2 g), and methylene chloride (100 mL), to give the captioned compound (4.2 g, 98%) as an oily product.

Sources & evidence

ORD record
ord-5d97a3a382c94017837b91d24dd25ea0
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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