Methyl iodide → HCID 67130680, compound

HRID 1746597Notes

Reaction equation

HRID 1746597 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([C:24]([OH:26])=[O:25])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:20][CH2:21][CH2:22][CH3:23])[CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:27](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[C:1]([O:5][C:6]([NH:8][C@H:9]([C:24]([O:26][CH3:27])=[O:25])[CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:20][CH2:21][CH2:22][CH3:23])[CH:12]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 67130666HCID 67130666, compound

Product 1

HCID 67130680HCID 67130680, compoundYield 65.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The same procedures as in Example 140 were carried out from the compound obtained in Example 139 (6.2 g), potassium carbonate (3.6 g), iodomethane (1.6 mL), and DMF (100 mL), to give the captioned compound (4.2 g, 65%) as an oily product.

Sources & evidence

ORD record
ord-6d84ce4facc549c9b3c0c3f17e8d95b1
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

Loading…