Triethylamine → HCID 67130467, compound

HRID 1746613Notes

Reaction equation

HRID 1746613 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.C(N(CC)CC)C.[CH3:25][C:26]([CH3:31])=[CH:27][C:28](O)=[O:29].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[CH3:25][C:26]([CH3:31])=[CH:27][C:28]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:29]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 109313-Methyl-2-butenoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2734891Methyl tryptophanate hydrochloride

Product 1

HCID 67130467HCID 67130467, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The same procedures as in Example 146 were carried out from methyl L-tryptophanate hydrochloride (3.0 g), triethylamine (2.0 mL), 3-methylcrotonic acid (1.4 g), WSC.HCl (2.7 g), and methylene chloride (80 mL), to give the captioned compound (2.7 g, 77%) as crystals.

Sources & evidence

ORD record
ord-e6d31142ede74870bc734b208566a7fb
Source dataset
uspto-grants-2015_10
Patent number
US09150510B2

Reaction notes

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