反应详情

温度

110 °C

A solution of cyclohexanone (10 g, 0.10 mol) in Toluene (100 ml) was treated with 2-methoxy ethylamine (8.4 g, 0.11 mol) and refluxed at 110° C. for 3 h. The reaction mass was cooled and diluted with ethanol (50 ml) and sodium borohydride (5.8 g, 0.15 mol) was added in portions at 0° C. The reaction mass was stirred at RT for 12 h and concentrated under reduced pressure. The residue was dissolved in water (100 ml), extracted with DCM (2×100ml), dried over sodium sulphate and evaporated. The crude material was purified by column chromatography by using DCM and methanol (98:2) as eluent to afford the title compound as a pale yellow liquid.

1. temperatureThe reaction mass was cooled
2. additionwas added in portions at 0° C
3. concentrationconcentrated under reduced pressure
4. dissolutionThe residue was dissolved in water (100 ml)
5. extractionextracted with DCM (2×100ml)
6. dry with materialdried over sodium sulphate
7. customevaporated
8. customThe crude material was purified by column chromatography