反应详情

The compound 10 (200 mg) was dissolved in ethyl acetate (1.7 mL) and dimethyl sulfoxide (0.84 mL), diisopropylethylamine (0.39 mL) was added, and the mixture was cooled in an ice bath. Sulfur trioxide-pyridine (256 mg) was added, and the mixture was stirred for 10 minutes, then poured into water, and extracted with ethyl acetate. The organic layer was washed with water and a saturated saline, dried with anhydrous magnesium sulfate, and then concentrated to obtain a titled compound (200 mg) having the following physical property values.

1. temperaturethe mixture was cooled in an ice bath
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materiala saturated saline, dried with anhydrous magnesium sulfate
5. concentrationconcentrated