反应详情

The compound 12 (250 mg) and (R)-2-methyl-CBS-oxazaborolidine (1M toluene solution; 0.135 mL) were dissolved in anhydrous tetrahydrofuran (1 mL), and a 1M borane-tetrahydrofuran complex (0.323 mL) was added at room temperature. The mixture was stirred for 10 minutes, methanol was then added, and the mixture was stirred for several minutes. This reaction liquid was diluted with ethyl acetate. This solution was washed with 1 M hydrochloric acid, water and a saturated saline, dried with anhydrous magnesium sulfate, and then concentrated to obtain a titled compound (220 mg) having the following physical property values.

1. additiona 1M borane-tetrahydrofuran complex (0.323 mL) was added at room temperature
2. stirringthe mixture was stirred for several minutes
3. customThis reaction liquid
4. washThis solution was washed with 1 M hydrochloric acid, water
5. dry with materiala saturated saline, dried with anhydrous magnesium sulfate
6. concentrationconcentrated