反应详情

温度

50 °C

Under the argon atmosphere, cesium carbonate (68 mg) and isopropyl iodide (0.016 mL) were added to a dimethylformamide (0.4 mL) solution of the compound 15 (20) (42.8 mg), and the mixture was stirred at 50° C. for 90 minutes. This was cooled to room temperature, ethyl acetate was then added, and the mixture was washed with water two times, and then with a saturated saline once. The mixture was dried with anhydrous magnesium sulfate, and then concentrated. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:3→1:1) to obtain a titled compound (34 mg) having the following physical property values.

1. temperatureThis was cooled to room temperature
2. washthe mixture was washed with water two times
3. dry with materialThe mixture was dried with anhydrous magnesium sulfate
4. concentrationconcentrated
5. customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:3→1:1)