Acetone → HCID 59478217, compound

HRID 1747030Notes

Reaction equation

HRID 1747030 reaction equation
[C:1]([O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:15]C(C)=O.C(=O)([O-])[O-].[K+].[K+].CI>O.C(OCC)(=O)C>[C:1]([O:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([O:12][CH3:15])=[O:11])=[CH:8][N:7]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

7

Reactant 4

HCID 180AcetoneHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 28996603HCID 28996603, compound

Product 1

HCID 59478217HCID 59478217, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
35 °C

Procedure

To a mixed liquid of 2163 mg of 6-tert-butoxynicotinic acid and 32 ml of acetone were added 2297 mg of potassium carbonate and 0.97 ml of methyl iodide, followed by stirring at 35° C. overnight. Ethyl acetate and water were added thereto to carry out liquid separation, and the organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain 1.191 g of methyl 6-tert-butoxynicotinate.

Workup

  1. customliquid separation
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-6a929b840edd4a9c9c252726e9386fc5
Source dataset
uspto-grants-2015_10
Patent number
US09150541B2

Reaction notes

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