反应详情

A mixture of [1-(2-amino-phenylamino)-cyclohexyl]-acetic acid methyl ester (205 mg, 0.79 mmol) in THF (5 mL) was added 1,1′-carbonyldiimidazole (180 mg, 1.11 mmol). The solution was stirred at room temperature for 16 hours. The reaction mixture was concentrated. The resulting residue was purified by CombiFlash with 50% EtOAc in Hexane as the eluent to afford the desired [1-(2-oxo-2,3-dihydro-benzimidazol-1-yl)-cyclohexyl]-acetic acid methyl ester (194 mg, 86%).

1. concentrationThe reaction mixture was concentrated
2. customThe resulting residue was purified by CombiFlash with 50% EtOAc in Hexane as the eluent