Hydrochloric Acid → HCID 178479023, compound

HRID 1747497Notes

Reaction equation

HRID 1747497 reaction equation
[ClH:1].[NH2:2][C:3]1[NH:7][N:6]=[C:5]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:4]=1>C(OCC)(=O)C>[ClH:1].[NH:11]1[CH2:10][CH2:9][CH:8]([C:5]2[CH:4]=[C:3]([NH2:2])[NH:7][N:6]=2)[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451767HCID 178451767, compound

Product 1

HCID 178479023HCID 178479023, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Hydrochloric acid (4 M solution in dioxane, 31.7 mL, 127 mmol) was added dropwise to a solution of tert-butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate (compound described in the pamphlet of WO2011/045344, 13.5 g, 50.7 mmol) in ethyl acetate (60 mL) under ice cooling, and the mixture was stirred at room temperature for 3 hours. Ethyl acetate (40 mL) was added to the reaction solution, and the mixture was stirred for 10 minutes. Then, the obtained precipitate was collected by filtration to obtain the title compound (12.5 g, yield: 100%).

Workup

  1. stirringthe mixture was stirred for 10 minutes
  2. filtrationThen, the obtained precipitate was collected by filtration

Sources & evidence

ORD record
ord-28ed71c8f33f4e898e017faeea294eec
Source dataset
uspto-grants-2015_10
Patent number
US09150575B2

Reaction notes

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