HCID 71293991, compound → HCID 71294061, compound

HRID 1747557Notes

Reaction equation

HRID 1747557 reaction equation
[F:1][C:2]([F:37])([F:36])[CH:3]([C:30]1[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=1)[O:4][C:5]1[C:6]([N:15](COCC[Si](C)(C)C)[S:16]([CH2:19][CH2:20][CH3:21])(=[O:18])=[O:17])=[N:7][C:8]2[C:13]([N:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2>FC(F)(F)C(O)=O>[F:37][C:2]([F:1])([F:36])[CH:3]([C:30]1[CH:31]=[CH:32][N:33]=[CH:34][CH:35]=1)[O:4][C:5]1[C:6]([NH:15][S:16]([CH2:19][CH2:20][CH3:21])(=[O:18])=[O:17])=[N:7][C:8]2[C:13]([N:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2

Participants

3

Reactant 1

HCID 71293991HCID 71293991, compound

Product 1

HCID 71294061HCID 71294061, compoundYield 102.9%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Compound B3 (48.9 mg, 0.0880 mmol) obtained in Step 1 was dissolved in trifluoroacetic acid (1.0 mL) and the solution was stirred at room temperature for 20 minutes. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1) to give Compound 42 (38.6 mg, 100% yield).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-cb89e57f586b423ba9330f165280cc4e
Source dataset
uspto-grants-2015_10
Patent number
US09150569B2

Reaction notes

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