Hydrochloric Acid → HCID 89586328, compound

HRID 1747801Notes

Reaction equation

HRID 1747801 reaction equation
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([CH:8]2[CH2:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)[N:4]=[C:3]1[C:21]1[N:25]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:24]=[CH:23][CH:22]=1.[ClH:32]>ClCCl.O1CCOCC1>[ClH:32].[C:26]1([N:25]2[C:21]([C:3]3[C:2](=[O:1])[CH:7]=[CH:6][N:5]([CH:8]4[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]4)[N:4]=3)=[CH:22][CH:23]=[N:24]2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 89586265HCID 89586265, compound

Product 1

HCID 89586328HCID 89586328, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 3-[4-oxo-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-1(4H)-yl]piperidine-1-carboxylate (15.9 g) in dichloromethane (76 mL) was added 4M hydrogen chloride in 1,4-dioxane solution (9.4 mL) at 0° C., and the mixture was stirred at room temperature for 24 hr. The solvent was evaporated under reduced pressure to give the title compound (12.1 g).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0e40d31d92e547309d1ae3742b1bdf78
Source dataset
uspto-grants-2015_10
Patent number
US09150588B2

Reaction notes

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