Benzyl Bromide → HCID 86723592, compound

HRID 1747802Notes

Reaction equation

HRID 1747802 reaction equation
CO[C:3]1[C:4](=[O:26])[C:5]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:18]=[CH:17][CH:16]=2)=[N:6][N:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:8]=1.[CH2:27]([Br:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(#N)C>[Br-:34].[CH2:27]([N+:12]1[CH:13]=[CH:14][C:9]([N:7]2[CH:8]=[CH:3][C:4](=[O:26])[C:5]([C:15]3[N:19]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:18]=[CH:17][CH:16]=3)=[N:6]2)=[CH:10][CH:11]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 58072472HCID 58072472, compound

Product 1

HCID 86723592HCID 86723592, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5-Methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-pyridin-4-ylpyridazin-4(1H)-one (0.49 g) and benzylbromide (0.25 mL) were dissolved in acetonitrile (30 mL), and the mixture was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained crystals were washed with ethyl acetate to give the title compound (0.73 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained crystals were washed with ethyl acetate

Sources & evidence

ORD record
ord-ed27ad0946f94b328c5d560d8fd02e73
Source dataset
uspto-grants-2015_10
Patent number
US09150588B2

Reaction notes

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