Methanol → HCID 66749795, compound

HRID 1748119Notes

Reaction equation

HRID 1748119 reaction equation
[O:1]=[S:2]1(=[O:28])[CH2:7][CH2:6][N:5]2[CH:8]=[CH:9][CH:10]=[C:11]([C:12]3[CH:13]=[C:14]4[C:18](=[CH:19][CH:20]=3)[N:17](C(OC(C)(C)C)=O)[CH:16]=[CH:15]4)[C:4]2=[N:3]1.[OH-].[Na+].CO>C1COCC1>[NH:17]1[C:18]2[C:14](=[CH:13][C:12]([C:11]3[C:4]4=[N:3][S:2](=[O:28])(=[O:1])[CH2:7][CH2:6][N:5]4[CH:8]=[CH:9][CH:10]=3)=[CH:20][CH:19]=2)[CH:15]=[CH:16]1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 66749880HCID 66749880, compound

Product 1

HCID 66749795HCID 66749795, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of tert-butyl 5-(2,2-dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)-1H-indole-1-carboxylate (500 mg) in THF (dry) (80 mL) was added 8 M NaOH aq. (8 mL). The mixture was stirred at 50° C. for 30 min. MeOH (20 mL) was added and the mixture was stirred at 50° C. for 4 hr.

Workup

  1. stirringthe mixture was stirred at 50° C. for 4 hr

Sources & evidence

ORD record
ord-376671b79921463fb604e13d58cf43d7
Source dataset
uspto-grants-2015_10
Patent number
US09150591B2

Reaction notes

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