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HRID1748229

反应详情

EQUATION

反应方程式

HRID 1748229 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)/C=C/[C@@H](C)C1=CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OC(C)=O)CC[C@]4(C)C3=CC[C@]12C
HCID25145011

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OC(C)=O)CC[C@]4(C)C3=CC[C@]12C
HCID59365567

未命名化合物

收率 96.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[O]=[Pt]=[O]
催化剂HCID345198

Platinic oxide

O2Pt

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a solution of compound 1.7a (17.5 g, 41 mmol) in EtOAc (350 mL) was added PtO2 (4.37 g), and the resulting slurry was hydrogenated in a Parr apparatus (70 psi) for 14-16 h. At this point the reaction was determined to be complete by TLC. The mixture was filtered through a small plug of Celite® and the solvent was removed under vacuum, affording compound 1.8a (17.0 g, 96.0%) as a white solid. The above product was used in the next step without further purification.

WORKUP

后处理

  1. filtrationThe mixture was filtered through a small plug of Celite®
  2. customthe solvent was removed under vacuum