反应详情

Trifluoromethanesulfonic acid (100 g) was added dropwise at room temperature into a dichloromethane solution (680 ml) containing 1-(4-fluorophenyl)-2-formylpyrrole (50.4 g), and stirred at reflux temperature for 13 hours. The reaction solution was poured into ice water, made alkaline with the addition of potassium carbonate and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo. The residue was purified with silica gel column chromatography (n-hexane/ethyl acetate) to give 1-(4-fluorophenyl)-3-formylpyrrole (34.5 g).

1. temperatureat reflux temperature for 13 hours
2. extractionextracted with chloroform
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated in vacuo
5. customThe residue was purified with silica gel column chromatography (n-hexane/ethyl acetate)