Hydrochloric Acid → HCID 86692556, compound

HRID 1748603Notes

Reaction equation

HRID 1748603 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[N:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=2)[C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+].Cl>O1CCCC1>[CH3:11][C:10]1[N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][N:13]=2)[N:8]=[N:7][C:6]=1[C:4]([OH:5])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86692557HCID 86692557, compound

Product 1

HCID 86692556HCID 86692556, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (681 mg) in tetrahydrofuran (10 ml) was added 1 N aqueous solution of sodium hydroxide (10 ml) at room temperature, and stirred at 80° C. for 9 hours. After completion of the reaction, 1 N hydrochloric acid aqueous solution (10 ml) was added thereto, and the solvent was evaporated. The obtained residue was washed with water, and dried in vacuo to give the titled compound (396 mg) as a brown solid.

Workup

  1. additionwas added
  2. customthe solvent was evaporated
  3. washThe obtained residue was washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-dfc227d25577498ba51dc60268d0566f
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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