Hydrochloric Acid → HCID 84010841, compound

HRID 1748605Notes

Reaction equation

HRID 1748605 reaction equation
C[O:2][C:3]([C:5]1[N:6]([CH3:20])[C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[N:8][CH:9]=1)=[O:4].[OH-].[Na+].Cl>O1CCCC1>[CH3:20][N:6]1[C:5]([C:3]([OH:4])=[O:2])=[CH:9][N:8]=[C:7]1[C:10]1[CH:11]=[CH:12][C:13]([C:16]([F:18])([F:17])[F:19])=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 44818303HCID 44818303, compound

Product 1

HCID 84010841HCID 84010841, compoundYield 86.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 3-methyl-2-[4-(trifluoromethyl)phenyl]-3H-imidazole-4-carboxylic acid methyl ester (962 mg) in tetrahydrofuran (10 ml) was added 1 N aqueous solution of sodium hydroxide (10 ml) at room temperature, and stirred at 80° C. for 1.5 hours. After completion of the reaction, 1 N hydrochloric acid aqueous solution (10 ml) was added thereto, and the solvent was evaporated. The obtained residue was washed with water, and dried in vacuo to give the titled compound (788 mg) as a gray solid.

Workup

  1. additionwas added
  2. customthe solvent was evaporated
  3. washThe obtained residue was washed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-fb638ff1a7994655a9183f3286da5264
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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