Hydroxylamine → HCID 178513301, compound

HRID 1748607Notes

Reaction equation

HRID 1748607 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[NH2:13][OH:14]>C(O)C>[OH:14][NH:13][C:7](=[NH:8])[C:6]1[CH:9]=[CH:10][C:3]([C:2]([F:1])([F:11])[F:12])=[CH:4][CH:5]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 67995Benzonitrile, 4-(trifluoromethyl)-

Product 1

HCID 178513301HCID 178513301, compoundYield 105.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 4-(trifluoromethyl)benzonitrile (10 g) in ethanol (100 ml) was added 50% hydroxylamine aqueous solution (11.6 g), and stirred at 80° C. overnight. After completion of the reaction, the solvent was evaporated, and water was added thereto. The insoluble matter was collected by filtration, and then dried to give N-hydroxy-4-(trifluoromethyl)benzamidine (12.6 g).

Workup

  1. customAfter completion of the reaction
  2. customthe solvent was evaporated
  3. additionwater was added
  4. filtrationThe insoluble matter was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-aeac104068884afc89d4dc3e5260a5f4
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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