Hydrogen chloride-ethyl acetate → HCID 86692575, compound

HRID 1748638Notes

Reaction equation

HRID 1748638 reaction equation
[ClH:1].C(OCC)(=O)C.[C:8]([C:10]1([C:17]2[N:22]=[CH:21][C:20]([NH:23][C:24]([C:26]3[CH:27]=[N:28][N:29]([C:32]4[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][N:33]=4)[C:30]=3[CH3:31])=[O:25])=[CH:19][CH:18]=2)[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1)#[N:9]>C(OCC)(=O)C>[ClH:1].[C:8]([C:10]1([C:17]2[N:22]=[CH:21][C:20]([NH:23][C:24]([C:26]3[CH:27]=[N:28][N:29]([C:32]4[CH:37]=[CH:36][C:35]([C:38]([F:40])([F:41])[F:39])=[CH:34][N:33]=4)[C:30]=3[CH3:31])=[O:25])=[CH:19][CH:18]=2)[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1)#[N:9]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86692576HCID 86692576, compound

Product 1

HCID 86692575HCID 86692575, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
70 °C

Procedure

4N HCl-Ethyl acetate (0.76 ml) was added to a solution of N-[6-(1-cyano-4-oxocyclohexyl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (285 mg) in ethyl acetate (60 ml) and stirred at 70° C. for an hour. After the reaction, the solvent was evaporated, ethanol was added, stirred at 70° C. for 0.5 hour and the precipitated solid was filtered to give the titled compound (270 mg) as a white solid.

Workup

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. additionethanol was added
  4. stirringstirred at 70° C. for 0.5 hour
  5. filtrationthe precipitated solid was filtered

Sources & evidence

ORD record
ord-009392154d734c4aaae4ef297f0ae5b3
Source dataset
uspto-grants-2015_10
Patent number
US09150555B2

Reaction notes

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