HRID1748676

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID6598

Dimethylcarbamoyl chloride

C3H6ClNO

HCID8471

Triethylamine

C6H15N

2 次

结构：Cc1cc(NC(=O)c2cnn(-c3ccc(C(F)(F)F)cn3)c2C)cnc1C1=CCNCC1

HCID86692538

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(NC(=O)c2cnn(-c3ccc(C(F)(F)F)cn3)c2C)cnc1C1=CCN(C(=O)N(C)C)CC1

HCID86692623

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Triethylamine (33 μl) and dimethylcarbamoyl chloride (22 μl) were added to a mixture of 5-methyl-N-[5-methyl-6-(1,2,3,6-tetrahydropyridin-4-yl)pyridin-3-yl]-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (100 mg) and dichloromethane (4.6 ml) and stirred at room temperature for two hours. Triethylamine (95 μl), water and ethanol were added to the reaction solution and the solvent was evaporated in vacuo. The precipitated solid was washed with water and ethanol to give the titled compound (66 mg) as a white solid.

WORKUP

后处理

customthe solvent was evaporated in vacuo
washThe precipitated solid was washed with water and ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d68734c3421445099dcc6acbf6a14b99
来源数据集: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09150555B2
来源说明: uspto-grants-2015_10

反应 SMILES

C(N(CC)CC)C.[CH3:8][N:9]([CH3:13])[C:10](Cl)=[O:11].[CH3:14][C:15]1[N:19]([C:20]2[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][N:21]=2)[N:18]=[CH:17][C:16]=1[C:30]([NH:32][C:33]1[CH:34]=[N:35][C:36]([C:40]2[CH2:41][CH2:42][NH:43][CH2:44][CH:45]=2)=[C:37]([CH3:39])[CH:38]=1)=[O:31].ClCCl>C(O)C.O>[CH3:8][N:9]([CH3:13])[C:10]([N:43]1[CH2:44][CH:45]=[C:40]([C:36]2[N:35]=[CH:34][C:33]([NH:32][C:30]([C:16]3[CH:17]=[N:18][N:19]([C:20]4[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][N:21]=4)[C:15]=3[CH3:14])=[O:31])=[CH:38][C:37]=2[CH3:39])[CH2:41][CH2:42]1)=[O:11]