HRID1748845

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID83693

L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-

C10H19NO4

结构：O=C(NCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OCC1c2ccccc2-c2ccccc21

HCID13783708

N~2~,N~6~-Bis{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-lysine

C36H34N2O6

PRODUCTS

生成物

结构：CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)O.O=C(NCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OCC1c2ccccc2-c2ccccc21

HCID131733567

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Dry Versabeads A-1900 (315-500 μm, 0.2 mmol NH2/g) (1.20 g) were dissolved in dry DMF (10 mL) and coupled with FmocLys(Fmoc)OH (0.24 mmol, 1 eq) and Boc-ValOH (0.48 mmol, 2 eq) using the general SPPS coupling procedure.

WORKUP

后处理

customDry

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dc7416805feb49c49a6c33eb89491d51
来源数据集: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09150899B2
来源说明: uspto-grants-2015_10

反应 SMILES

[NH:1]([C:28]([O:30][CH2:31][CH:32]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[C:38]2[C:33]1=[CH:34][CH:35]=[CH:36][CH:37]=2)=[O:29])[C@H:2]([C:25]([OH:27])=[O:26])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][CH:12]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]2[C:13]1=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:9].[NH:45]([C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[C@H:46]([C:50]([OH:52])=[O:51])[CH:47]([CH3:49])[CH3:48]>CN(C=O)C>[NH:1]([C:28]([O:30][CH2:31][CH:32]1[C:44]2[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=2)[C:38]2[C:33]1=[CH:34][CH:35]=[CH:36][CH:37]=2)=[O:29])[C@H:2]([C:25]([OH:27])=[O:26])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][CH:12]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]2[C:13]1=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:9].[NH:45]([C:53]([O:55][C:56]([CH3:58])([CH3:57])[CH3:59])=[O:54])[C@H:46]([C:50]([OH:52])=[O:51])[CH:47]([CH3:49])[CH3:48]