Hydrochloric Acid → HCID 58313086, compound

HRID 1748866Notes

Reaction equation

HRID 1748866 reaction equation
[CH2:1]1[C:5]2([CH2:10][CH2:9][O:8][CH2:7][CH2:6]2)[CH2:4][C@@H:3]([C:11]([O:13]CC)=[O:12])[N:2]1[C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17].O.[OH-].[Li+].Cl>C1COCC1.O.CO>[C:20]1([CH2:19][O:18][C:16]([N:2]2[C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]3([CH2:10][CH2:9][O:8][CH2:7][CH2:6]3)[CH2:1]2)=[O:17])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 58313162HCID 58313162, compound

Product 1

HCID 58313086HCID 58313086, compound

Reagents, catalysts & solvents 1

HCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

To a solution of 3-ethyl 2-(phenylmethyl) (3S)-8-oxa-2-azaspiro[4.5]decane-2,3-dicarboxylate (120) (300 mg, 0.86 mmol) in THF/water/methanol (3 mL/1.5 mL/1.5 mL) was added lithium hydroxide monohydrate (72 mg, 1.7 mmol) and the reaction stirred at room temperature for 30 min. The reaction was treated with 1N HCl (2 mL) and partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc and the organic layer dried over MgSO4 and concentrated in vacuo to afford the title compound in quantitative yield. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.54-12.93 (m, 1H) 7.21-7.47 (m, 5H) 4.90-5.20 (m, 2H) 4.11-4.41 (m, 1H) 3.44-3.70 (m, 5H) 3.24 (dd, J=15.0, 11.7 Hz, 1H) 2.32 (td, J=13.6, 8.5 Hz, 1H) 1.73 (ddd, J=16.8, 12.9, 7.2 Hz, 1H) 1.38-1.64 (m, 4H). LC-MS ESI (M−H)−=318.19.

Workup

  1. custompartitioned between EtOAc and water
  2. extractionThe aqueous layer was extracted with EtOAc
  3. dry with materialthe organic layer dried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1aa9359e96494365a84ca5dc5a0fa2a3
Source dataset
uspto-grants-2015_10
Patent number
US09150587B2

Reaction notes

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