Ethyl Lactate → HCID 346572, compound

HRID 1748967Notes

Reaction equation

HRID 1748967 reaction equation
[C:1]([O:6]CC)(=O)[CH:2]([CH3:4])[OH:3].[NH2:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12]>C(O)C>[C:1]([NH:9][C:10]([CH3:14])([CH3:13])[CH2:11][OH:12])(=[O:6])[CH:2]([CH3:4])[OH:3]

Participants

4

Reactant 2

HCID 7344Ethyl LactateHCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 346572HCID 346572, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
112.5 °C

Procedure

15 g of ethyl lactate and 10 g of 2-amino-2-methyl-1-propanol were mixed and subsequently heated to 110-115° C. for 3.5 hours. During the reaction, the ethanol formed was distilled off. After the reaction, the excess of ethyl lactate was removed by vacuum distillation (bottom temperature: 160° C., 7 mbar), using a vigreux column. 15.5 g of residual brown viscous liquid was collected, which was confirmed to be pure N-lactoyl 2-amino-2-methylpropanol by NMR analysis.

Workup

  1. customDuring the reaction
  2. distillationwas distilled off
  3. customAfter the reaction
  4. customthe excess of ethyl lactate was removed by vacuum distillation (bottom temperature: 160° C., 7 mbar)
  5. custom15.5 g of residual brown viscous liquid was collected

Sources & evidence

ORD record
ord-5ea3950e5bf94a078808b5427f690440
Source dataset
uspto-grants-2015_10
Patent number
US09155329B2

Reaction notes

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