反应详情

A mixture of sorafenib (5 gm), p-toluenesulfonic acid (3 gm), dimethylformamide (15 ml) and methanol (10 ml) were stirred for 20 minutes at room temperature. To the reaction mass was added methanol (80 ml) at 0 to 5° C. and stirred for 1 hour 30 minutes. The separated solid was filtered to obtain a wet solid. To the wet solid was added methanol (75 ml) and stirred for 2 hours at room temperature. The separated solid was filtered and then dried at 65 to 70° C. for 11 hours to obtain 4.9 gm of sorafenib tosylate polymorph III.

1. stirringstirred for 1 hour 30 minutes
2. filtrationThe separated solid was filtered
3. customto obtain a wet solid
4. stirringstirred for 2 hours at room temperature
5. filtrationThe separated solid was filtered
6. customdried at 65 to 70° C. for 11 hours