Potassium Carbonate → HCID 69040835, compound

HRID 1749141Notes

Reaction equation

HRID 1749141 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]1[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:20]=[CH:19][C:18]=1[F:27]>CN(C=O)C>[F:27][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]([C:23]([F:24])([F:25])[F:26])[C:17]=1[CH2:16][N:6]1[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:8]=[N:7]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 163764-nitro-1H-pyrazoleHCID 27375732-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

Product 1

HCID 69040835HCID 69040835, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

4-Nitropyrazole (Aldrich; 4.974 g, 44.0 mmol) was dissolved in DMF (100 ml) and potassium carbonate (9.12 g, 66.0 mmol) was added. The reaction mixture was allowed to stir at ambient temperature under nitrogen for approximately 5 minutes. 2-(Bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene (Aldrich; 11.31 g, 44.0 mmol) in DMF (25 ml) was then added over a period of approximately 5 minutes and the reaction was left to stir overnight.

Workup

  1. waitthe reaction was left
  2. stirringto stir overnight

Sources & evidence

ORD record
ord-5cddcc80b74942c18cd83f1d41c89e33
Source dataset
uspto-grants-2015_10
Patent number
US09156791B2

Reaction notes

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