反应详情

温度

50 °C

To a solution of 2-bromopyridine (1.1 g, 6.85 mmol) was added n-BuLi (2.7 mL, 6.85 mmol 2.5M in hexane) at −78° C. After stirring for 15 min, a solution of Example 44B (1.0 g, 4.57 mmol) in THF (20 mL) was added. The mixture was stirred at −78° C. for 15 min. followed by slow addition of 9.1 mL of 1 M H2SO4. The mixture was then heated to 50° C. and stirred for 30 min. The aqueous phase was separated and extracted with EtOAc (30 mL).

1. stirringThe mixture was stirred at −78° C. for 15 min.
2. stirringstirred for 30 min
3. customThe aqueous phase was separated
4. extractionextracted with EtOAc (30 mL)