Hydroxyamine hydrochloride → HCID 118162127, compound

HRID 1749388Notes

Reaction equation

HRID 1749388 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][C:5](=O)[CH2:4][C:3]1([CH3:10])[CH3:9].Cl.[NH2:12][OH:13].C(=O)(O)[O-].[Na+]>CO>[OH:1][CH:2]1[CH2:7][CH2:6]/[C:5](=[N:12]\[OH:13])/[CH2:4][C:3]1([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 114992344-Hydroxy-3,3-dimethylcyclohexanone

Product 1

HCID 118162127HCID 118162127, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of 4-hydroxy-3,3-dimethylcyclohexanone (1.0 equiv.), hydroxylamine hydrochloride (2.0 equiv.) and sodium bicarbonate (2.5 equiv.) in MeOH (0.7 M) was stirred at room temperature overnight. The solvent were removed and the residue was passed through a short silica gel column (50% ethyl acetate in petroleum ether) to afford the crude (E)-4-hydroxy-3,3-dimethylcyclohexanone oxime (96% yield) as a colorless oil.

Workup

  1. customThe solvent were removed

Sources & evidence

ORD record
ord-68718fb1c8ab4b2681c6210ebede6228
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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