Dimethylformamide dimethyl acetal → HCID 118162249, compound

HRID 1749427Notes

Reaction equation

HRID 1749427 reaction equation
[O:1]=[C:2]([CH2:6][CH3:7])[CH2:3][C:4]#[N:5].CO[CH:10](OC)[N:11]([CH3:13])[CH3:12]>C1COCC1>[CH3:13][N:11]([CH:10]=[C:3]([C:2](=[O:1])[CH2:6][CH3:7])[C:4]#[N:5])[CH3:12]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 99203693-oxopentanenitrile

Product 1

HCID 118162249HCID 118162249, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3-oxopentanenitrile (1.0 equiv.) and 1,1-dimethoxy-N,N-dimethylmethanamine (4.3 M) in THF (1.6 M) was stirred at room temperature overnight. After reaction completion, the solvent was removed under vacuum to give the crude 2-((dimethylamino)methylene)-3-oxopentanenitrile (0.98 equiv.), which was used for the next step without further purification. MS (ESI) m/z 152.1 [M+H]+.

Workup

  1. customAfter reaction completion
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-1aae11c619764dcfb4a2cbc9a30917f4
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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