Trifluoroacetic acid → HCID 118162172, compound

HRID 1749458Notes

Reaction equation

HRID 1749458 reaction equation
[C:1]([C:3]1[CH:18]=[CH:17][C:6]([CH2:7][CH2:8][NH:9]C(=O)OC(C)(C)C)=[CH:5][C:4]=1[O:19][C:20]([F:23])([F:22])[F:21])#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:9][CH2:8][CH2:7][C:6]1[CH:17]=[CH:18][C:3]([C:1]#[N:2])=[C:4]([O:19][C:20]([F:21])([F:22])[F:23])[CH:5]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118162111HCID 118162111, compound

Product 1

HCID 118162172HCID 118162172, compoundYield 115.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-cyano-3-(trifluoromethoxy)phenethylcarbamate (150 mg, 0.45 mmol) in DCM (3 mL) was added TFA (1.5 mL). The resulting reaction mixture was stirred at room temperature for 1.5 h. The mixture was concentrated to afford the crude title product (120 mg, crude), which was used directly for next step without further purification. MS (ESI) m/z 231.1 [M+H]+.

Workup

  1. customThe resulting reaction mixture
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-425470a65cc84a879f74cfc72c890875
Source dataset
uspto-grants-2015_10
Patent number
US09156798B2

Reaction notes

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