HCID 178488169, compound → HCID 178488168, compound

HRID 1749872Notes

Reaction equation

HRID 1749872 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[CH2:12][OH:13]>C(OCC)(=O)C.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[CH:12]=[O:13]

Participants

4

Reactant 1

HCID 178488169HCID 178488169, compound

Product 1

HCID 178488168HCID 178488168, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of (5-methoxy-1H-indazol-3-yl)methanol (0.367 g, 2.06 mmol) in ethyl acetate (20 mL) was added with manganese dioxide (1.79 g, 20.6 mmol), and the mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, and then the filtrate was concentrated to obtain 5-methoxy-1H-indazole-3-carbaldehyde (0.254 g, 70%).

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-e7d9ea70ca694760a0b4a5e5b630d0fb
Source dataset
uspto-grants-2015_10
Patent number
US09156827B2

Reaction notes

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