反应详情

5.0 g of N-bromosuccinimide was added to a mixture of 4.6 g of methyl-(5-pentafluoroethyl-pyridin-2-yl)-amine and 70 ml of acetonitrile, and the mixture was stirred at room temperature for 8 hours. A saturated aqueous sodium thiosulfate solution and an aqueous sodium bicarbonate solution were added to the mixture, and the mixture was extracted with ethyl acetate. The combined organic layer was dried over sodium sulfate and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 6.3 g of (3-bromo-5-pentafluoroethyl-pyridin-2-yl)-methyl-amine.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe combined organic layer was dried over sodium sulfate
3. concentrationconcentrated under reduced pressure