反应详情

Excess HCl in EtOAc was added dropwise to a solution of intermediate 30 (800 mg, 2.5 mmol) in EtOAc and the reaction mixture was stirred at rt for 1.5 h. Filtration gave 1-(2-ethoxyphenyl)-1,4-diazepane hydrochloride (intermediate 31) (382 mg, 59%) as a white solid.

1. filtrationFiltration