Hydrochloric Acid → 1-(2-Isopropoxyphenyl)-1,4-diazepane hydrochloride

HRID 1750104Notes

Reaction equation

HRID 1750104 reaction equation
[ClH:1].[CH:2]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:18][CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)([CH3:4])[CH3:3]>CCOC(C)=O>[ClH:1].[CH:2]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:18][CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66632190Tert-butyl 4-(2-isopropoxyphenyl)-1,4-diazepane-1-carboxylate

Product 1

HCID 666318431-(2-Isopropoxyphenyl)-1,4-diazepane hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Excess HCl in EtOAc was added dropwise to a solution of intermediate 33 (172 mg, 0.51 mmol) in EtOAc and the reaction mixture was stirred at rt for 1.5 h. Filtration gave 1-(2-isopropoxyphenyl)-1,4-diazepane hydrochloride (intermediate 34) (175 mg, 100%) as a white solid.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-40286f37db244a8186b4c552e1b9b984
Source dataset
uspto-grants-2015_10
Patent number
US09156822B2

Reaction notes

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