反应详情

Excess HCl in EtOAc was added dropwise to a solution of intermediate 33 (172 mg, 0.51 mmol) in EtOAc and the reaction mixture was stirred at rt for 1.5 h. Filtration gave 1-(2-isopropoxyphenyl)-1,4-diazepane hydrochloride (intermediate 34) (175 mg, 100%) as a white solid.

1. filtrationFiltration