Hydrochloric Acid → 1-(2,3-Dichlorophenyl)piperazine hydrochloride

HRID 1750112Notes

Reaction equation

HRID 1750112 reaction equation
Cl.[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1>CCOC(C)=O>[ClH:2].[Cl:2][C:3]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66632014HCID 66632014, compound

Product 1

HCID 116303721-(2,3-Dichlorophenyl)piperazine hydrochlorideYield 167.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

Excess HCl in EtOAc was added dropwise to a solution of intermediate 40 (11.1 g, 33.5 mmol) in EtOAc and the reaction mixture was stirred at rt for 1.5 h. Filtration gave 1-(2,3-dichlorophenyl)piperazine hydrochloride salt (intermediate 41) (7.5 g, 78%) as a white solid. HPLC: 99%, RT 2.052 min. MS (ESI) m/z 231.0[M+H]+.

Workup

  1. filtrationFiltration

Sources & evidence

ORD record
ord-0cc2d93d81de4dfb9f7aad52071ca8a7
Source dataset
uspto-grants-2015_10
Patent number
US09156822B2

Reaction notes

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