Hydrochloric Acid → HCID 178446057, compound

HRID 1750179Notes

Reaction equation

HRID 1750179 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:13][S:14][C:15]1[NH:19][CH:18]=[N:17][N:16]=1)[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[CH3:11][CH:10]([CH3:12])[CH2:9][C@H:8]([NH2:7])[CH2:13][S:14][C:15]1[NH:19][CH:18]=[N:17][N:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178445930HCID 178445930, compound

Product 1

HCID 178446057HCID 178446057, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

160 mg of [(S)-3-Methyl-1-(4H-[1,2,4]triazol-3-ylsulfanylmethyl)-butyl]-carbamic acid tert-butyl ester were reacted with 2.6 ml of 4M hydrochloric acid in dioxane at it for 2 h. The reaction was concentrated in vacuo and the resulting crude product was used without further purification. 125 mg (100%) of (S)-3-methyl-1-(4H-[1,2,4]triazol-3-ylsulfanylmethyl)-butylamine-hydrochloride were obtained.

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe resulting crude product was used without further purification

Sources & evidence

ORD record
ord-695db5fe1c6f4a55b4f76c28da6fec22
Source dataset
uspto-grants-2015_10
Patent number
US09156796B2

Reaction notes

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