Hydrochloric Acid → HCID 178446826, compound

HRID 1750181Notes

Reaction equation

HRID 1750181 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:13][S:14]([C:17]1[NH:21][CH:20]=[N:19][N:18]=1)(=[O:16])=[O:15])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[CH3:11][CH:10]([CH3:12])[CH2:9][CH:8]([NH2:7])[CH2:13][S:14]([C:17]1[NH:21][CH:20]=[N:19][N:18]=1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178445931HCID 178445931, compound

Product 1

HCID 178446826HCID 178446826, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

200 mg of [(S)-3-Methyl-1-(4H-[1,2,4]triazole-3-sulfonylmethyl)-butyl]-carbamic acid tert-butyl ester were dissolved in 6 ml of dioxane and reacted with 2.2 ml of 4M hydrochloric acid in dioxane at rt for 16 h. The reaction was concentrated in vacuo and the resulting crude product was used without further purification. 120 mg (100%) of S)-3-Methyl-1-(4H-[1,2,4]triazole-3-sulfonylmethyl)-butylamine-hydrochloride were obtained.

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe resulting crude product was used without further purification

Sources & evidence

ORD record
ord-b4a914b92ac64c7799448d3021359a6c
Source dataset
uspto-grants-2015_10
Patent number
US09156796B2

Reaction notes

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